GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs962856 | 1 | rs6739392 | chr2:67601971 | ETAA1 | chr2:67624442-67637533:+ | -0.18 | -4.19 | 3.33E-5 | Pancreatic cancer |
| THCA | cis | rs6748734 | 1 | rs6739772 | chr2:241840711 | C2orf54 | chr2:241825466-241835573:- | 0.3 | 6.31 | 6.41E-10 | Urinary metabolites |
| THCA | cis | rs4820834 | 1 | rs67401267 | chr22:30750209 | MTP18 | chr22:30805176-30825041:+ | 0.23 | 3.36 | 0.00083 | Coronary artery calcification |
| THCA | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | ALMS1P | chr2:73872046-73912692:+ | 0.71 | 11.38 | 9.89E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | NAT8 | chr2:73867850-73869537:- | 0.38 | 6.04 | 3.13E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | TPRKB | chr2:73956957-73964517:- | -0.18 | -4.59 | 5.76E-6 | Metabolite levels |
| THCA | cis | rs11125529 | 1 | rs6740641 | chr2:54482989 | C2orf73 | chr2:54558071-54588714:+ | 0.3 | 4.43 | 1.15E-5 | Telomere length |
| THCA | cis | rs9914544 | 1 | rs67411574 | chr17:18797337 | FAM18B | chr17:18684582-18710026:+ | -0.42 | -10.71 | 3.77E-24 | Educational attainment (years of education) |
| THCA | cis | rs9914544 | 1 | rs67411574 | chr17:18797337 | FBXW10 | chr17:18647326-18682661:+ | -0.23 | -4.98 | 8.93E-7 | Educational attainment (years of education) |
| THCA | cis | rs6741172 | 1 | rs6741172 | chr2:106440059 | MRPS9 | chr2:105654483-105716417:+ | -0.14 | -3.36 | 0.000836 | Addiction |
| THCA | cis | rs8170 | 1 | rs67412075 | chr19:17385502 | ABHD8 | chr19:17402941-17414282:- | 0.25 | 4.1 | 4.84E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs67412075 | chr19:17385502 | ANKLE1 | chr19:17392454-17398454:+ | 0.29 | 4.91 | 1.28E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs8170 | 1 | rs67412075 | chr19:17385502 | OCEL1 | chr19:17337055-17340027:+ | 0.21 | 4.21 | 3.04E-5 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| THCA | cis | rs11825709 | 1 | rs67412659 | chr11:93714389 | HEPHL1 | chr11:93754378-93847374:+ | 0.43 | 3.55 | 0.00042 | Obesity-related traits |
| THCA | cis | rs4663866 | 1 | rs6741269 | chr2:239179418 | LOC151174 | chr2:239133754-239140318:- | 0.49 | 5.35 | 1.35E-7 | Irritable bowel syndrome |